RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Sp1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
MTT ASSAY; PCR etc.
Target
SP1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-beta and MAPKs Pathways in Cardiac Fibroblasts
Year
2015
Function
miR-7a/b has an anti-fibrotic role in ang ii-treated cardiac fibroblasts (CFs) that is mediated by sp1 mechanism involving the TGF-beta and MAPKs pathways.